Research results

Publications

2026.04 - 2027.03

1. Global approval and certification of ophthalmic AI devices: A comparative regulatory perspective.
   Grzybowski A, Liu T Y A, Popovic M M., Zhao A, Miyake M, Takahashi H, Kawasaki R, He M, Gong X, Goktas P, Jin K.  Asia Pac J Ophthalmol. 2026 May-Jun;15(3). doi: 10.1016/j.apjo.2026.100328. Epub 2026 May 8.

2025.04 - 2026.03

1. Promoter H3K4me3 and Gene Expression Involved in Systemic Metabolism Are Altered in Fetal Calf Liver of Nutrient-Restricted Dams.
   S Muroya, K Ojima, S Shimamoto, T Sugasawa, T Gotoh. Int J Mol Sci. 2025 Aug 4;26(15):7540.
   doi: 10.3390/ijms26157540.
2. The antitumor mechanism of oclacitinib in canine lymphoma.
   M Harada, T Sugasawa, T Mizuno, et al. Sci Rep. 2026 Feb 12;16(1):8427. doi: 10.1038/s41598-026-40066-9.
3. Development of Detection Method Using Dried Blood Spot with Next-Generation Sequencing and LabDroid for Gene Doping Control.
   K Maehara, T Sugasawa, et al. Int Mol Sci. 2025 Jun 26;26(13):6129. doi: 10.3390/ijms26136129.
4. RNA Sequencing Reveals Effects of a New Complex Bath Additive on Cultured Cells.
   N Otani, K D M Nguyen, J Wan, Y Kanki, T Sugasawa. Cosmetics. 2025:12(3), 98. doi: 10.3390/cosmetics12030098.
5. Immunoreceptor CD300a regulates ischemic tissue damage and adverse remodeling in the mouse heart and kidney.
   N Nishiyama, T Sugasawa, A Shibuya, et al. J Clin Invest. 2025 Jul 24;135(19):e184984. doi: 10.1172/JCI184984. eCollection 2025 Oct 1.
6. One year outcomes of intravitreal faricimab for treatment Naïve neovascular AMD and associations with baseline aqueous humor cytokines.
   S Inoda, H Takahashi, Y Yanagi, et al. Sci Rep. 2025 Dec 29;15(1):44717. doi: 10.1038/s41598-025-28911-9.
7. Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases.
   Y Bhak, A Tenesa, et al. (Collaborators: Hidenori Takahashi, Hiroshi Takahashi, Y inoue, et al.) Sci Rep. 2025 Aug 28;15(1):31721. doi: 10.1038/s41598-025-10031-z.
8. Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution.
   R Edahiro, Y Okada, et al. (Collaborators: Hidenori Takahashi, Hiroshi Takahashi, Y inoue, et al.) Nat Genet. 2025 Aug;57(8):1905-1921. doi: 10.1038/s41588-025-02266-3. Epub 2025 Jul 28.
9. Artificial Intelligence–Derived Biomechanical Index for Early Corneal Ectasia Detection: Advancing Beyond Tomography.
   H Abdelmotaal, H Takahashi, S Yousefi, et al. Ophthalmol Sci. 2025 Sep 30;6(1):100952. doi: 10.1016/j.xops.2025.100952. eCollection 2026 Jan.
10. Real-World Outcomes of Brolucizumab Treatment in Japanese Patients with Neovascular Age-Related Macular Degeneration: A 12-Month, Multicenter Study.
    M Ohnaka, H Takahashi, et al. Ophthalmol Ther. 2025 Jul;14(7):1551-1565. doi: 10.1007/s40123-025-01159-2. Epub 2025 May 28.
11. Constraining Reionization with Lyα Damping-wing Absorption in Galaxy Spectra: A Machine Learning Model Based on Reionization Simulations.
    H Park, I Jung, H Yajima, J G Sorce, P R Shapiro, K Ahn, P Ocvirk, R Teyssier, G Yepes, I T Iliev, J S W Lewis. Astrophysical Journal. 2025 Apr; 983(2). doi: 10.3847/1538-4357/adc001.
12. Alpha Particle Emitter Radiolabeled Antibodies in Cancer Therapy.
    C R A P Palangka, I Mahendra, R Ritawidya, N Kondo, T Nakajima. Pharmaceuticals (Basel). 2025 Sep 2;18(9):1316. doi: 10.3390/ph18091316.
13. Integrative Analysis of 18F-FDG PET Radiomics and mRNA Expression in Recurrent/Metastatic Oral Squamous Cell Carcinoma.
    M Kim, W Gu, R Kawabata- Iwakawa, S Kina, T Nakajima, T Higuchi, M Ogawa, K Suzuki, Y Tsushima, S Yokoo. Mol Imaging Biol. 2025 Jun;27(3):421-430. doi: 10.1007/s11307-025-02012-5. Epub 2025 May 14.
14. In vivo detection of HER2-positive breast cancer and sentinel lymph node metastasis using activatable ICG-conjugated Trastuzumab.
    Y Liu, M Isa, T Nakajima. Front Oncol. 2026 Jan 14:15:1747065. doi: 10.3389/fonc.2025.1747065. eCollection 2025.
15. Multi–b-value diffusion-weighted imaging–derived parameters for differentiating high-grade serous ovarian carcinoma from other epithelial ovarian cancers.
    T Saida, M Yoshida, T Amano, M Shindo, R Nemoto, T Iizuka, A Shikama, T Satoh, T Nakajima. Jpn J Radiol. 2025 Oct;43(10):1678-1687. doi: 10.1007/s11604-025-01813-6. Epub 2025 Jul 1.
16. Evaluation of lumbar intervertebral disc degeneration using 23Na-MRI in clinical settings.
    Y Nakahashi, T Saida, M Yoshida, M Shindo, K Yamada, T Ishimori, M Terakado, T Amano, T Ishiguro, J Kwon, T Nakajima. Skeletal Radiol. 2025 Dec;54(12):2725-2734. doi: 10.1007/s00256-025-04968-5. Epub 2025 Jun 16.
17. Mediating role of frailty/pre-frailty on the association between exercise participation and traffic crashes among Japanese community-dwelling older drivers.
    J Liu, Y Fujii, K Fujii, J Seol, K Nagata, T Okura. 2025 May 15;25(1):341. doi: 10.1186/s12877-025-05998-3.
18. Unrecognised sleep disturbances in patients with cirrhosis diagnosed with a portable electroencephalogram device.
    A Uchiyama, H Kamimura, S Miida, H Maruyama, T Tonouchi, J Seol, T Kokubo, T Okura, Y Watanabe, N Kimura, H Abe, A Sakamaki, T Yokoo, S Terai. BMJ Health Care Inform. 2026 Jan 5;33(1):e101526. doi: 10.1136/bmjhci-2025-101526.
19. Relationship between bioelectrical impedance–derived muscle quality and physical activity, sedentary behavior, or sleep using compositional data analysis (CoDA).
    Y Asano, M Miyachi, H Nanri, H Murakami, Y Gando, T Nakagata, T Yoshida, T Okura, Y Yamada. Sci Rep. 2025 Dec 18;15(1):44108. doi: 10.1038/s41598-025-27953-3.
20. Gender-specific factors affecting changes in physical function among older adults during the COVID-19 pandemic.
    K Teraoka, T Tsuji, T Monma, N Lim, T Okura. Sci Rep. 2025 Sep 1;15(1):32033. doi: 10.1038/s41598-025-16990-7.
21. Changes in cycling and incidences of functional disability and mortality among older Japanese adults.
    K Tsunoda, K Nagata, T Jindo, Y Soma, N Kitano, Y Fujii, T Okura. Transportation Research Part F: Traffic Psychology and Behaviour. 2025 May:3 (296-305). doi: 10.1016/j.trf.2025.03.006.
22. Segmental phase angle and the extracellular to intracellular water ratio are associated with functional disability in community-dwelling older adults: A follow-up study of up to 12 years.
    Y Asano, K Tsunoda, K Nagata, N Lim, T Tsuji, K Shibuya, T Okura. Nutrition. 2025 May:133:112709.
    doi: 10.1016/j.nut.2025.112709. Epub 2025 Feb 7.
23. Multi-task exercise increases delta power in non-rapid eye movement sleep among older female adults: A randomized crossover trial.
    J Lee, K Nagata, J Seol, I Park, K Tokuyama, M Yanagisawa, T Okura. Neuroimage. 2025 Apr 15:310:121105. doi: 10.1016/j.neuroimage.2025.121105. Epub 2025 Feb 27.
24. Sex- and age-related declines in muscle mass, strength, physical performance, and muscle quality among community-dwelling older adults: A cross-sectional study.
    Y Asano, T Yoshida, K Tsunoda, K Yokoyama, Y Watanabe, Y Yoshinaka, T Okura, M Kimura, Y Yamada. Exp Gerontol. 2025 Oct 15:210:112862. doi: 10.1016/j.exger.2025.112862. Epub 2025 Aug 14.
25. A regression analytical model of serum levodopa metabolic profile in Parkinson's disease.
    A Chukyo, S Saiki, et al.  Heliyon. 2026 Mar:12(3). doi: 10.1016/j.heliyon.2026.e44615
26. Associations between maternal blood lead concentration during pregnancy and trajectories of wheezing and asthma in offspring: The Japan Environment and Children’s Study (JECS).
    Y Nishihama, T Isobe, Y Ohya, T Murata, S F Nakayama. Environ Int. 2026 Apr:210:110219.
     doi: 10.1016/j.envint.2026.110219. Epub 2026 Mar 28.
27. Associations between antenatal organophosphate pesticide exposure and pregnancy outcomes: The Japan Environment and Children's Study (JECS).
    S Baba, K Tanigawa, S F Nakayama, Y Nishihama, K Hirata, S Ikehara, J Miyazaki, R Kawasaki, H Iso. Sci Total Environ. 2025 Oct 1:997:180117. doi: 10.1016/j.scitotenv.2025.180117. Epub 2025 Aug 5.
28. A benchmark dose analysis of the blood cadmium concentration in pregnant women using the Japan Environment and Children’s Study data.
    N Suwannarin, Y Nishihama, T Isobe, H Okubo, S F Nakayama. Environ Int. 2026 Feb:208:110041.
    doi: 10.1016/j.envint.2025.110041. Epub 2025 Dec 30.
29. Association between urinary organophosphate pesticide metabolites and blood lipid levels in US children.
    N Morimoto, H Kikuchi, Y Nishihama, E Sohara, S Uchida, S F Nakayama. Ecotoxicol Environ Saf. 2025 Nov 1:306:119330. doi: 10.1016/j.ecoenv.2025.119330. Epub 2025 Nov 6.
30. Determinants of plasma poly- and perfluoroalkyl substances during pregnancy: The Japan Environment and Children's Study.
    Y Lai, S F Nakayama, Y Nishihama, T Isobe. Ecotoxicol Environ Saf. 2025 Apr 1:294:118107.
     doi: 10.1016/j.ecoenv.2025.118107. Epub 2025 Mar 29.
31. Utility of synthetic musculoskeletal gaits for generalizable healthcare applications.
    Y Yamada, M Kobayashi, K Shinkawa, E Bilal, J Liao, M Nemoto, M Ota, K Nemoto, T Arai. Nat Commun. 2025 Jul 4;16(1):6188. doi: 10.1038/s41467-025-61292-1.
32. Diabetes mellitus and cardiac disease as key predictors of rituximab-induced acute thrombocytopenia in ANCA-associated vasculitis.
    S Akao, K Maruo, H Miki, Isao Matsumoto. et al. Rheumatology (Oxford). 2026 Jan 8;65(1):keaf529. doi: 10.1093/rheumatology/keaf529.
33. T follicular helper 1 cells in blood potentially mirror salivary gland-infiltrating T cells in Sjögren’s disease.
    S Abe, H Tsuboi, H Aoki, H Toko, F Honda, H Miki, H Asashima, Y Kondo, I Matsumoto. Sci Rep. 2025 Jul 2;15(1):23520. doi: 10.1038/s41598-025-07008-3.
34. White Matter Integrity of the Corpus Callosum Mediates the Association Between Aging and Skin Condition.
    D Yuan, K Kokubun, K Nemoto, Y Yamakawa. Life (Basel). 2025 Oct 24;15(11):1664. doi: 10.3390/life15111664.
35. Dual-task walking for early detection of Alzheimer’s disease: comparative analysis of tasks using whole-body gait variables.
    R Katagiri, Y Yamada, K Shinkawa, M Kobayashi, M Nemoto, M Ota, K Nemoto, T Arai, K Takiyama. BMC Geriatr. 2025 Oct 24;25(1):807. doi: 10.1186/s12877-025-06389-4.
36. What kind of emotional intelligence enhances what kind of cultural intelligence: Analysis using emotional and cultural intelligence facets of expatriates.
    K Kokubun, K Nemoto, Y Yamakawa. International Journal of Intercultural Relations. 2026 Jan; 110. doi: 10.1016/j.ijintrel.2025.102332.
37. Cultural and emotional intelligence correlates with healthy lifestyles.
    K Kokubun, K Nemoto, Y Yamakawa. Acta Psychol (Amst). 2025 May:255:104854.
     doi: 10.1016/j.actpsy.2025.104854. Epub 2025 Mar 25.
38. Estimating covariate-balanced survival curve in distributed data environment using data collaboration quasi-experiment.
    A Toyoda, Y Kawamata, T Nakayama, A Imakura, T Sakurai, Y Okada. Sci Rep. 2026 Jan 12;16(1):3368. doi: 10.1038/s41598-025-33245-7.
39. New solutions based on the generalized eigenvalue problem for the data collaboration analysis.
    Y Kawakami, Y Takano, A Imakura. Information Sciences. 2026 Jan; 723. doi: 10.1016/j.ins.2025.122642
40. Estimation of conditional average treatment effects on distributed confidential data.
    Y Kawamata, R Motai, Y Okada, A Imakura, T Sakurai. Expert Systems with Applications. 2026 Jan 15; 296, Part C. doi: 10.1016/j.eswa.2025.129066.
41. Data collaboration for causal inference from limited medical testing and medication data.
    T Nakayama, Y Kawamata, A Toyoda, A Imakura, R Kagawa, M Sanuki, R Tsunoda, K Yamagata, T Sakurai, Y Okada. Sci Rep. 2025 Mar 21;15(1):9827. doi: 10.1038/s41598-025-93509-0.
42. Pause before action: Waiting short time as a simple and resource-rational boost.
    M Shirasuna, R Kagawa, H Honda. Sci Rep. 2025 Feb 5;15(1):4362. doi: 10.1038/s41598-025-87119-z.
43. Molecular evolution of the Wood-Ljungdahl pathway and the reductive glycine pathway in Desulfobacterota.
    T Wakashima, K Kume, Y Chiba. Front Microbiol. 2026 Jan 9:16:1708584.
     doi: 10.3389/fmicb.2025.1708584. eCollection 2025.
44. Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors.
    M Kubota, S Yoshida, et al. BMC Med. 2026 Jan 16;24(1):89. doi: 10.1186/s12916-026-04634-0.
45. Job Loss after Cancer Diagnosis among Working-Age Cancer Survivors.
    R Yamamoto, Y M Nakao, S Yoshida, M Yuno, C B Becker, T Nakayama, K Kawakami. Cancer Epidemiol Biomarkers Prev. 2026 Feb 3;35(2):284-291. doi: 10.1158/1055-9965.EPI-25-1146.
46. Assessing the risk of gastrointestinal perforation associated with COVID-19: a self-controlled case series study.
    T Okura, S Tanaka-Mizuno, T Fukasawa, S Yoshida, K Kawakami. Am J Epidemiol. 2025 Oct 7;194(10):2837-2843. doi: 10.1093/aje/kwae448.
47. Effectiveness of short active breaks for reducing sedentary behavior and increasing physical activity among Japanese office workers: one-year quasi-experimental study.
    N Kitano, T Jindo, K Yoshiba, D Yamaguchi, Y Fujii, K Wakaba, K Maruo, Y Kai, Takashi Arao. Scand J Work Environ Health.  2025 Jul 1;51(4):312-322. doi: 10.5271/sjweh.4224. Epub 2025 Apr 8.
48. Permutation-based global rank test with adaptive weights for multiple primary endpoints.
    S Yoshida, Y Yamaguchi, K Maruo, M Gosho. Stat Methods Med Res. 2025 Jun;34(6):1254-1266.
     doi: 10.1177/09622802251334886. Epub 2025 May 14.
49. Effects of optimal timed automatic awakening from a short daytime nap on cognitive performance, alertness, and fatigue.
    Y Suzuki, C Suzuki, Y Suzuki, F Kawana, T Ohigashi, K Maruo, T Watanabe, T Abe. Sci Rep. 2025 Oct 24;15(1):37228. doi: 10.1038/s41598-025-21008-3.
50. Long-term outcomes of concurrent chemo-proton therapy for unresectable stage III non-small cell lung cancer: a Japanese national registry study.
    H Iwata, M Murakami, K Maruo, et al. Radiother Oncol. 2026 Jan:214:111307. doi: 10.1016/j.radonc.2025.111307. Epub 2025 Nov 26.
51. Clinical outcomes of proton beam therapy for inoperable stage I-IIA non-small cell lung cancer: Japanese nationwide registry study.
    M Nakamura, K Maruo, et al. Radiother Oncol. 2025 Jun:207:110868. doi: 10.1016/j.radonc.2025.110868. Epub 2025 Mar 22.
52. Bladder Preservation Therapy in Combination with Atezolizumab and Radiation Therapy (BPT-ART) for Invasive Bladder Cancer: Final Analysis from a Multicentre, Open-label, Prospective Phase 2 Trial.
    Y Nagumo, K Maruo, H Nishiyama, et al. Eur Urol. 2026 Jan 17:S0302-2838(25)04872-9. doi: 10.1016/j.eururo.2025.12.019. Online ahead of print.
53. The prognostic effect of recurrent laryngeal nerve palsy after esophagectomy in locally advanced esophageal squamous cell carcinoma: A multi-center retrospective study.
    K Ogawa, T Toyozumi, K Noma, Y Akashi, Y Owada, M Hashimoto, Z Saze, M Kano, Y Nabeya, K Kono, T Fujiwawa, K Maruo, et al. Eur J Surg Oncol. 2025 Sep;51(9):110151. doi: 10.1016/j.ejso.2025.110151. Epub 2025 May 13.
54. Phase II trial dedicated to non-selected, pretreated cutaneous angiosarcoma: Efficacy of nivolumab (AngioCheck Study).
    Y Fujisawa, K Namikawa, S Ishitsuki, K Yoshino, T Isei, H Kato, T Yanagi, Y Yamamoto, H Uchi, M Yasuda, K Maruo, et al. Eur J Cancer. 2025 Jun 25:224:115537. doi: 10.1016/j.ejca.2025.115537. Epub 2025 Jun 1.
55. Lung ultrasound for predicting surfactant administration in ventilated and non-ventilated infants with respiratory distress syndrome: a multicenter prospective study.
    Y Hoshino, T Futatani, S Kitamura, T Sato, K Maruo, et al. Eur J Pediatr. 2025 Nov 10;184(12):742.
     doi: 10.1007/s00431-025-06580-0.
56. A Novel Bilateral Data Fusion Approach for EMG-Driven Deep Learning in Post-Stroke Paretic Gesture Recognition.
    A Anastasiev, H Kadone, A Marushima, H Watanabe, A Zaboronok, S Watanabe, A Matsumura, K Suzuki, Y Matsumaru, H Nishiyama, E Ishikawa. Sensors. 2025 Jun 11;25(12):3664.
     doi: 10.3390/s25123664.
57. Additional outlet occlusion as an important factor in avoiding retreatment after transvenous embolization for cavernous sinus dural arteriovenous fistulas.
    S Miyamoto, W Tsuruta, J Isozaki, D Ishigami, H Hosoo, Y Ito, A Marushima, M Hayakawa, Y Matsumaru. J Neurointerv Surg. 2025 Jun 16;17(7):717-724. doi: 10.1136/jnis-2024-021773.
58. The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan.
    M Sekiya, K Kainoh, W Chen, D Yamazaki, T Tsuyuzaki, Y Kobari, A Nakata, K Saito, N Aono-Soma, A Majid, H Ohno, T Miyamoto, T Matsuzaka, R Nakajima, T Matsuda, Y Murayama, Y Sugano, Y Osaki, H Iwasaki, H Shimano. Nat Aging. 2025 Nov;5(11):2197-2214. doi: 10.1038/s43587-025-00973-4. Epub 2025 Oct 8.
59. Longitudinal association of SGLT2 inhibitors and GLP-1RAs on falls in persons with type 2 diabetes.
    Y Suzuki, H Suzuki, K Maruo, T Matsuda, Y Murayama, Y Sugano, Y Osaki, H Iwasaki, M Sekiya, Y Hada, H Shimano. Sci Rep. 2025 Mar 17;15(1):9178. doi: 10.1038/s41598-025-91101-0.

2024.04 - 2025.03

1. Communication difficulties among individuals with hearing impairments during the COVID-19 pandemic and their associated factors: a cross-sectional study using a national survey in Japan.
   Watanabe T, Sugiyama T, Suzuki A, Tamiya N. BMC Public Health. 2025 Mar 14;25(1):1002. doi: 10.1186/s12889-025-22108-5. PMID: 40087703 Free PMC article. 2023 Jul 21;10(7):866. doi: 10.3390/bioengineering10070866.
2. Genome-Wide Mapping of Autonomously Replicating Sequences in the Marine Diatom Phaeodactylum tricornutum.
   H S Yun, K Yoneda, T Sugasawa, I Suzuki, Y Maeda. Mar Biotechnol(NY). 2024 Nov 28;27(1):14. doi: 10.1007/s10126-024-10390-0.
3. Whole Mitochondrial DNA Sequencing Using Fecal Samples from Domestic Dogs.
   T Sugasawa, K D M Nguyen, N Otani, K Maehara, F Kamiya, A Hirokawa, T Takemasa, K Watanabe, T Nishi, K Sato, S Shimmura, Y Takahashi, Y Kanki. Animals(Basel). 2024 Oct 5;14(19):2872.
    doi: 10.3390/ani14192872.
4. Uremia Impedes Skeletal Myocyte Myomixer Expression and Fusogenic Activity: Implication for Uremic Sarcopenia.
   T Higashihara, M Odawara, H Nis, T Sugasawa, Y Suzuki, S Kametaka, R Inagi, M Nangaku. Am J Pathol. 2024 May;194(5):759-771.
    doi: 10.1016/j.ajpath.2024.01.005.
5. Empirical Myoelectric Feature Extraction and Pattern Recognition in Hemiplegic Distal Movement Decoding.
   A Anastasiev, H Kadone, A Marushima, H Watanabe, A Zaboronok, S Watanabe, A Matsumura, K Suzuki, Y Matsumaru , E Ishikawa. Bioengineering (Basel). 2023 Jul 21;10(7):866.
    doi: 10.3390/bioengineering10070866.
6. Comparative Pharmacokinetic Analysis of Aflibercept and Brolucizumab in Human Aqueous Humor Using Nano-Surface and Molecular-Orientation Limited Proteolysis.
   K Nagaoka, N Kimura, S Inoda, T Takayama, Y Arai, Y Yanagi , T Shimada, R Nagai, H Takahashi, K Aizawa. Int J MOl Sci. 2025 Jan 10;26(2):556. doi: 10.3390/ijms26020556.
7. One-year outcome of brolucizumab for neovascular age-related macular degeneration in Japanese patients.
   S Inoda, H Takahashi, R Takahashi, Y Hashimoto, H Yoshida, R Tsukii, H Takahashi, H Kawashima, Sci Rep. Y Yanagi. 2024 Jan 30;14(1):2451. doi: 10.1038/s41598-024-52747-4.
8. One-year visual and anatomical outcomes of intravitreal faricimab injection for neovascular age-related macular degeneration after prior brolucizumab treatment.
   H Takahashi, S Inoda, H Takahashi, R Takahashi, Y Hashimoto, H Yoshida, H Kawashima, Y Yanagi. Sci Rep. 2024 Apr 20;14(1):9087.
    doi: 10.1038/s41598-024-59894-8.
9. Incidence and risk factors of intraocular inflammation after brolucizumab treatment in Japan: A Multicenter Age-Related Macular Degeneration Study.
   S Inoda, H Takahashi, et al. Retina. 2024 Apr 1;44(4):714-722.
    doi: 10.1097/IAE.0000000000004009.
10. Artificial Intelligence in Obstetric and Gynecological MR Imaging.
    T Saida, W Gu, S Hoshiai, T Ishiguro, M Sakai, T Amano, Y Nakahashi, A Shikama, T Satoh, T Nakajima. Magn Reson Med Sci. 2025 Jul 1;24(3):354-365. doi: 10.2463/mrms.rev.2024-0077.
11. The Utility of Apparent Water Diffusion Coefficient Maps for Evaluating the Presence of Myometrial Invasion in Patients with Endometrial Cancer.
    M Yoshida, T Saida, S Shibuki, T Ishiguro, M Sakai, T Amano, T Satoh, T Nakajima. Magn Reson Med Sci. 2025 Sep 26;24(4):2024-0048. doi: 10.2463/mrms.mp.2024-0048.
12. Diagnostic imaging analysis to differentiate struma ovarii from mucinous carcinomas, encompassing T2*-based imaging, diffusion-weighted imaging, and dynamic contrast-enhanced imaging.
    T Ishiguro, T Saida, A Shikama, A Akiyama, Y Tenjimbayashi, K Mori, T Satoh, T Nakajima. Br J Radiol. 2024 Nov 1;97(1163):1843-1849. doi: 10.1093/bjr/tqae165.
13. Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis.
    T Tanaka, K Kojo, T Suetomi, Y Nagumo, H Midorikawa, T Matsuda, A Nakazono, T Shimizu, S Fujimoto, A Ikeda, S Kandori, H Negoro, T Takayama, H Nishiyama. Nutrients. 2025 Feb 28;17(5):867. doi: 10.3390/nu17050867.
14. Objective Evaluation of Gaze Location Patterns Using Eye Tracking During Cystoscopy and Artificial Intelligence-Assisted Lesion Detection.
    A Ikeda, K Izumi, K Katori, H Nosato, K Kobayashi, S Suzuki, S Kandori, M Sanuki, Yoichi Ochiai, H Nishiyama. J Endourol. 2024 Aug;38(8):865-870. doi: 10.1089/end.2023.0699. Epub 2024 Apr 16.
15. Inductively Coupled Plasma Mass Spectrometry Performance for the Measurement of Key Serum Minerals: A Comparative Study With Standard Quantification Methods.
    K Kojo, T Oguri, T Tanak, A Ikeda , T Shimizu , S Fujimoto , A Nakazono, Y Nagumo, S Kandori, H Negoro, H Nishiyama. J Clin Lab Anal. 2025 Jan;39(2):e25140. doi: 10.1002/jcla.25140.
16. Association between blood lipid levels in early pregnancy and urinary organophosphate metabolites in the Japan Environment and Children's Study.
    N Morimoto, Y Nishihama, K Onishi, S F Nakayama. Environ Int. 2024 Aug:190:108932. doi: 10.1016/j.envint.2024.108932. Epub 2024 Aug 3.
17. Brain Healthcare Quotient as a Tool for Standardized Approach in Brain Healthcare Interventions.
    K Yoshida, K Nemoto, A Hamano, M Kawamori , T Arai, Y Yamakawa. Life (Basel). 2024 Apr 26;14(5):560. doi: 10.3390/life14050560.
18. Vocal expression of emotions discriminates dementia with Lewy bodies from Alzheimer's disease.
    M Kobayashi, Y Yamada, K Shinkawa, M Nemoto, M Ota, K Nemoto, T Arai. Alzheimers Dement(Amst). 2024 May 8;16(2):e12594. doi: 10.1002/dad2.12594.
19. LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation.
    R K Gupta, D S Figueroa, K Fung, H Miki, J Miller, F Ay, M Croft. J Autoimmun. 2024 Apr:144:103177. doi: 10.1016/j.jaut.2024.103177. Epub 2024 Feb 17.
20. Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment.
    K Kokubun, K Nemoto, T Ikaga, Y Yamakawa. Neuroimage. 2025 Mar:308:121033. doi: 10.1016/j.neuroimage.2025.121033. Epub 2025 Jan 25.
21. Collaborative causal inference on distributed data.
    Y Kawamata, R Motai, Y Okada, A Imakura, T Sakurai. Expert Systems with Applications. 15 June 2024. doi: 10.1016/j.eswa.2023.123024.
22. The nature of anchor-biased estimates and its application to the wisdom of crowds.
    H Honda, R Kagawa, M Shirasuna. Cognition. 2024 May:246:105758.
     doi: 10.1016/j.cognition.2024.105758. Epub 2024 Mar 4.
23. IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts.
    R Okino, K Mukai, S Oguri, M Masuda, S Watanabe, Y Yoneyama, S Nagaosa, T Miyamoto, A Mochizuki, S Takahashi, F Hakuno. Sci Rep. 2024 Sep 5;14(1):20699. doi: 10.1038/s41598-024-71739-y.
24. An expanded phylogenomic analysis of Heterolobosea reveals the deep relationships, non-canonical genetic codes, and cryptic flagellate stages in the group.
    T Pánek, A K Tice, P Corre, P Hrubá, D Žihala, R Kamikawa, E Yazaki, T Shiratori, K Kume, et al. Mol Phylogenet Evol. 2025 Mar:204:108289.
     doi: 10.1016/j.ympev.2025.108289. Epub 2025 Jan 16.
25. Effects of thienopyridine class antiplatelets on bleeding outcomes following robot-assisted radical prostatectomy.
    M Kubota, M Kawakita, S Yoshida, et al. Sci Rep. 2024 Mar 11;14(1):5847. doi: 10.1038/s41598-024-56570-9.
26. Comparative effectiveness and cardiovascular safety of romosozumab versus teriparatide in patients with osteoporosis: a population-based cohort study.
    S Masuda, T Fukasawa, S Matsuda, S Yoshida, K Kawakami. Osteoporos Int. 2024 Dec;35(12):2165-2174. doi: 10.1007/s00198-024-07255-6. Epub 2024 Sep 25.
27. Comparison of Omron and ActiGraph monitors in estimating daily step counts and time spent in moderate to vigorous physical activity in free-living adults.
    H Shimura, S Okada, K Maruo, K Daimaru, N Deguchi, Y Fujiwara, H Sasai. BMJ Open Sport Exerc Med. 2025 Mar 6;11(1):e002402.
     doi: 10.1136/bmjsem-2024-002402. eCollection 2025.
28. geessbin: an R package for analyzing small-sample binary data using modified generalized estimating equations with bias-adjusted covariance estimators.
    R Ishii, T Ohigashi, K Maruo, M Gosho. BMC Med Res Methodol. 2024 Nov 13;24(1):277. doi: 10.1186/s12874-024-02368-2.
29. Cardiorespiratory fitness and body mass index on metabolic syndrome in middle-aged Japanese adults under national health guidance: a cross-sectional study.
    X Zhai, S S Sawada, S Kurosawa, S Koriyama, S A Dimitroff, S Sato, Y Oguma, Y Nakata, K Maruo, M Miyachi, Y Gando, K Oka, D C Lee. BMC Public Health. 2024 Jul 30;24(1):2050. doi: 10.1186/s12889-024-19544-0.
30. Systematic review and meta-analysis of photon radiotherapy versus proton beam therapy for pediatric intracranial ependymoma: TRP-ependymoma 2024.
    M Mizumoto, S Hosaka, K Nakai, Y Li, Y Oshiro, T Iizumi, T Saito, M Inaba, H Fukushima, R Suzuki, S Shimizu, K Maruo, H Sakurai. Heliyon.2024 Nov 14;10(22):e40372. doi:10.1016/j.heliyon.2024.e40372. eCollection 2024 Nov 30.
31. Particle Therapy for Intrahepatic Cholangiocarcinoma: A Multicenter Prospective Registry Study, Systematic Review and Meta-Analysis.
    M Mizumoto, K Shibuya, K Terashima, M Murakami, M Murakami, Y Shioyama, Y Matsuo, T Ogino, T Ohno, T Waki, H Ogino, H Tamamura, N Katoh, M Wakatsuki, T Okimoto, M Suzuki, T Saito, S Toyama, T Hashimoto, H Ohba, S Kubo, K Hasegawa, K Maruo, H Sakurai. Liver Cancer. 2024 Aug 28;14(2):211-222. doi:10.1159/000540291. eCollection 2025 Apr.
32. Simple imputation method for meta-analysis of survival rates when precision information is missing.
    K Maruo, Y Yamaguchi, R Ishii, H Noma, M Gosho. Res Synth Methods. 2025 Nov;16(6):937-952. doi: 10.1017/rsm.2025.10024. Epub 2025 Sep 11.
33. Feasibility, Acceptability, and Potential Efficacy of a Mobile Health Application for Community-Dwelling Older Adults with Frailty and Pre-Frailty: A Pilot Study.
    T Ohta, Y Osuka, T Shida, K Daimaru, N Kojima, K Maruo, A Iizuka, M Kitago, Y Fujiwara, H Sasai. Nutrients. 2024 Apr 16;16(8):1181. doi: 10.3390/nu16081181.
34. Potential Bias Models With Bayesian Shrinkage Priors for Dynamic Borrowing of Multiple Historical Control Data. Ohigashi T, Maruo K, Sozu T, Sawamoto R, Gosho M. Pharm Stat. 2025 Mar-Apr;24(2):e2453. doi: 10.1002/pst.2453. Epub 2024 Nov 17.
35. Image Quality Evaluation for Brain Soft Tissue in Neuroendovascular Treatment by Dose-Reduction Mode of Dual-Axis “Butterfly” Scan.
    Hosoo H, Ito Y, Hirata K, Hayakawa M, Marushima A, Masumoto T, Yamagami H, Matsumaru Y. AJNR Am J Neuroradiol. 2025 Feb 3;46(2):285-292. doi: 10.3174/ajnr.A8472.
36. Factors Associated with Non-attendance at a Follow-up Visit for Dyslipidemia Identified at Health Checkups: A Retrospective Cohort Study in a Japanese Prefecture.
    Taniguchi Y, Iwagami M, Sugiyama T, Kuroda N, Yamaoka T, Inokuchi R, Suzuki A, Watanabe T, Irie F, Tamiya N. JMA J. 2024 Oct 15;7(4):518-528. doi: 10.31662/jmaj.2024-0065. Epub 2024 Oct 3. PMID: 39513054 Free PMC article.
37. Estimating and Predicting the Rate of Kidney Function Decline over 10 Years in the General Population.
    Iwagami M, Odani K, Saito T. Kidney360. 2024 Dec 1;5(12):1862-1870. doi: 10.34067/KID.0000000608. Epub 2024 Oct 8. PMID: 39451006 Free PMC article.
38. Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
    Iwagami M, et al. GBD 2021 Stroke Risk Factor Collaborators. Lancet Neurol. 2024 Oct;23(10):973-1003. doi: 10.1016/S1474-4422(24)00369-7. PMID: 39304265 Free article.
39. Comparison of machine-learning and logistic regression models for prediction of 30-day unplanned readmission in electronic health records: A development and validation study.
    Iwagami M, Inokuchi R, Kawakami E, Yamada T, Goto A, Kuno T, Hashimoto Y, Michihata N, Goto T, Shinozaki T, Sun Y, Taniguchi Y, Komiyama J, Uda K, Abe T, Tamiya N. PLOS Digit Health. 2024 Aug 20;3(8):e0000578. doi: 10.1371/journal.pdig.0000578. eCollection 2024 Aug. PMID: 39163277 Free PMC article.

Awards and External Funding

1. Under preparation.